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CAS

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1152858-54-2

5-Amino-1-(2-Fluorobenzyl)-1H-pyrazole is an organic compound that serves as a crucial intermediate in the synthesis of various chemical compounds, particularly tetrazole derivatives. It is characterized by its unique molecular structure, which includes a pyrazole ring and a fluorobenzyl group, making it a versatile building block in the pharmaceutical and chemical industries.

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  • 1152858-54-2 Structure

  • Basic information

    1. Product Name: 5-Amino-1-(2-Fluorobenzyl...
    2. Synonyms: 5-Amino-1-(2-Fluorobenzyl...;5-AMino-1-(2-Fluorobenzyl)-1H-pyrazole
    3. CAS NO:1152858-54-2
    4. Molecular Formula: C10H10FN3
    5. Molecular Weight: 191.2049032
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1152858-54-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 368.6±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.26±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 3.78±0.10(Predicted)
    10. CAS DataBase Reference: 5-Amino-1-(2-Fluorobenzyl...(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-Amino-1-(2-Fluorobenzyl...(1152858-54-2)
    12. EPA Substance Registry System: 5-Amino-1-(2-Fluorobenzyl...(1152858-54-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1152858-54-2(Hazardous Substances Data)

1152858-54-2 Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-1-(2-Fluorobenzyl)-1H-pyrazole is used as a key intermediate for the synthesis of tetrazole derivatives, which are known for their potential as orexin receptor antagonists. These antagonists play a significant role in the treatment of various diseases by targeting the orexin system, which is involved in regulating wakefulness and appetite.
Application Reason:
The compound's unique structure allows for the development of new drugs that can effectively modulate the orexin system, offering potential therapeutic benefits for patients suffering from conditions such as insomnia, narcolepsy, and certain addiction disorders. By acting as an intermediate in the synthesis of these tetrazole derivatives, 5-Amino-1-(2-Fluorobenzyl)-1H-pyrazole contributes to the advancement of pharmaceutical research and drug development in the treatment of these diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 1152858-54-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,2,8,5 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1152858-54:
(9*1)+(8*1)+(7*5)+(6*2)+(5*8)+(4*5)+(3*8)+(2*5)+(1*4)=162
162 % 10 = 2
So 1152858-54-2 is a valid CAS Registry Number.

1152858-54-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(2-fluorophenyl)methyl]pyrazol-3-amine

1.2 Other means of identification

Product number -
Other names 1-(2-Fluorobenzyl)-1H-pyrazol-5-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1152858-54-2 SDS

1152858-54-2Upstream product

1152858-54-2Downstream Products

1152858-54-2Relevant articles and documents

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

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Page/Page column 15, (2011/04/25)

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

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Page/Page column 37, (2010/01/07)

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases

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, (2008/06/13)

The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.

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