SYNGAS REACTIONS II. THE HOMOGENEOUS CATALYZED CARBONYLATION AND CYCLIZATION OF ALLYLIC SUBSTRATES
Carbon monoxide insertion and/or addition to allylic precursors may lead to the formation of both linear and cyclic carbonylation products.In examining these competing reaction paths, rhodium, platinum, palladium and nickel-based homogeneous catalysts have been developed which are particularly useful for the selective synthesis of γ-butyrolactam, N-alkyl-2-pyrrolidones, vinylacetate and phenylacetate esters and diesters from a variety of allylic and benzylic substrates.The extension of this catalysis to the carbonylation of certain vinylic and propargyl congeners hasalso been considered.
The synthesis of amidoesters has been investigated by anodic cooxidation of diacid hemiesters CO2H-CH2-Z-CO2CH3 -CH2-> and amidoacids R1-N(Y)-(CH2)2-CO2H .The scope of this reaction was examined in detail.This synthetic pathway provided very a simple access to a wide range of amidoesters R1-N(Y)-(CH2)3-Z-CO2CH3 by varying Z and R1 as well as n value.
Abderrahman, Ben Moufida,Laurent, Eliane,Marquet, Bernard
p. 571 - 578
(2007/10/02)
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