- Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles
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Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.
- Kobayashi, Eiji,Togo, Hideo
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p. 3723 - 3735
(2019/09/30)
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- Synthesis of N-Phenylalkanehydrazonoyl Chlorides
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N-Phenylalkanehydrazonoyl chlorides (5), hitherto unknown, were synthesized from the corresponding arylhydrazides of aliphatic carboxylic acids (1) with triphenylphosphine-carbon tetrachloride in good yields.Keywords-N-phenylalkanehydrazonoyl chloride; ar
- Sakamoto, Takeshi,Kikugawa, Yasuo
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p. 800 - 802
(2007/10/02)
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