The synthesis of a series of adenosine A3 receptor agonists
A series of 1′-(6-aminopurin-9-yl)-1′-deoxy-N-methyl-β-D-ribofuranuronamides that were characterised by 2-dialkylamino-7-methyloxazolo[4,5-b]pyridin-5-ylmethyl substituents on N6 of interest for screening as selective adenosine A3 receptor agon
Broadley, Kenneth J.,Burnell, Erica,Davies, Robin H.,Lee, Alan T. L.,Snee, Stephen,Thomas, Eric J.
p. 3765 - 3781
(2016/05/09)
Efforts towards the identification of simpler platensimycin analogues-the total synthesis of oxazinidinyl platensimycin
The total synthesis and biological testing of oxazinidinyl platensimycin, the methyl ester analogues, and the simplified oxazinidinyl analogue were investigated to identify simpler platensimycin analogues. The study also investigated the possibilities of replacing enone moiety of platensimycin with the oxazinidinyl ring to create a potential bioisostere compound. The study examined the possibilities to replace the tetracyclic core structure of platensimycin with other motifs that are synthetically easier to access. Proposed methods can applied to the construction of other polycyclic motifs found in the other natural or non-natural molecules. The results show that the enone moiety of platensimycin's core structure is sensitive to modifications.
Wang, Jingxin,Lee, Vincent,Sintim, Herman O.
supporting information; experimental part
p. 2747 - 2750
(2009/12/06)
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