- THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING
-
The invention is directed to compounds of the formula: wherein each of the variables are defined herein, as well as methods of making and using the compounds as agonists of S1P1 and/or S1P5 for instance treating an autoimmune disease.
- -
-
Paragraph 0195
(2017/01/26)
-
- A Convenient Synthesis of Fluorobenzoic Acid Esters via Direct Halogen Exchange
-
The reaction of chlorobenzoic acid esters with potassium fluoride in the presence of thermally stable phase-transfer catalysts was investigated.The yields of fluorinated products strongly depended on the structure of the substrates employed.
- Yoshida, Yasuo,Furusawa, Osamu,Kimura, Yoshikazu
-
p. 301 - 305
(2007/10/02)
-
- Fluorobenzoates and process for their production
-
A fluorobenzoate having the formula: STR1 wherein X is a fluorine atom or a hydrogen atom, and R is an alkyl group.
- -
-
-
- Phenyl pyridones and insectidal use thereof
-
A compound of formula (I) STR1 wherein R1, R2, R4 and R5 are independently selected from hydrogen, halogen, lower alkyl optionally substituted by halogen, lower alkoxy optionally substituted by halogen and lower alkenyl optionally substituted by halogen; R3 is halogen, amino, mono- or di(lower alkyl)-amino, lower alkyl substituted by halogen, lower alkoxy optionally substituted by halogen and lower alkenyl optionally substituted by halogen provided that R3 is not monochloro or monobromo-methyl; R6 is oxygen or sulphur; R7 and R10 are independently selected from hydrogen, halogen, lower alkyl optionally substituted by halogen, lower alkoxy optionally substituted by halogen, and lower thioalkoxy optionally substituted by halogen; and R8 is hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower thioalkoxy, cyano, nitro, optionally substituted oximino, optionally substituted lower alkenyl, optionally substituted aryloxy, optionally substituted amino or S(O)nR11 wherein n is 0, 1 or 2 and R11 is optionally substituted lower alkyl; R9 is hydrogen, or lower alkyl optionally substituted by halogen, lower alkenyl optionally substituted by halogen or CO2 R12 wherein R12 is lower alkyl optionally substituted by halogen; provided that R1, R2, R3, R4 and R5 are not all hydrogen; and further provided that when R3 is trifluoromethyl and R1 and R5 are halogen, R2 and R4 are not both hydrogen, or R7, R8, R9 and R10 do not comprise from one to four halogen or trihalomethyl substituents.
- -
-
-