1155603-09-0

Basic information

• Product Name: 8-broMo-2-ethylquinolin-4-ol
• Synonyms: 8-broMo-2-ethylquinolin-4-ol
• CAS NO: 1155603-09-0
• Molecular Formula: C11H10BrNO
• Molecular Weight: 252.1072
• Mol File: 1155603-09-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-broMo-2-ethylquinolin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-broMo-2-ethylquinolin-4-ol(1155603-09-0)
• EPA Substance Registry System: 8-broMo-2-ethylquinolin-4-ol(1155603-09-0)

Safety Data

• Hazardous Substances Data: 1155603-09-0(Hazardous Substances Data)

Relevant articles and documents

NOVEL BICYCLIC COMPOUND OR SALT THEREOF

Provided is a novel bicyclic compound which has an HSP90 inhibitory effect and a carcinostatic effect. Also provided is a pharmaceutical agent which is based on the HSP90 inhibitory effect and is useful in the prevention and/or treatment of a disease involving HSP90, particularly, cancer. The present invention provides a compound represented by the following general formula (I) or a salt thereof wherein at least one of X1, X2, X3, and X4 represents N or N-oxide and the rest thereof are the same or different and each represent C—R2; any one or two of Y1, Y2, Y3, and Y4 represent C—R4 and the rest thereof are the same or different and each represent CH or N;R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O;R2 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.;R3 represents a hydrogen atom, —CO—R5 etc.;R4 represents a hydrogen atom, —CO—R6, —N(R7)(R8) etc.;R5 represents a hydroxyl group, an amino group etc.;R6 represents a hydroxyl group etc.;R7 and R8 are the same or different and each represent a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; and R9 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.