115705-72-1

Basic information

• Product Name: Pyrimido[5,4-g]quinazoline-4,6(1H,7H)-dione, 5,10-dihydroxy-2,8-dimethyl- (9CI)
• Synonyms: Pyrimido[5,4-g]quinazoline-4,6(1H,7H)-dione, 5,10-dihydroxy-2,8-dimethyl- (9CI)
• CAS NO: 115705-72-1
• Molecular Formula: C12H10N4O4
• Molecular Weight: 274.23
• Mol File: 115705-72-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimido[5,4-g]quinazoline-4,6(1H,7H)-dione, 5,10-dihydroxy-2,8-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimido[5,4-g]quinazoline-4,6(1H,7H)-dione, 5,10-dihydroxy-2,8-dimethyl- (9CI)(115705-72-1)
• EPA Substance Registry System: Pyrimido[5,4-g]quinazoline-4,6(1H,7H)-dione, 5,10-dihydroxy-2,8-dimethyl- (9CI)(115705-72-1)

Safety Data

• Hazardous Substances Data: 115705-72-1(Hazardous Substances Data)

Upstream product

• 115705-48-1 2,8-dimethylpyrimido<5,4-g>quinazoline-4,5,6,10(3H,7H)-tetrone 

Relevant articles and documents

Synthesis and Electrochemistry of Pyrimidoquinazoline-5,10-diones. Design of Hydrolytically Stable High Potential Quinones and New Reductive Alkylation Systems

The synthesis of pyrimidoquinazoline-5,10-diones 1 and pyrimidoquinazoline-5,10-diones 2 was carried out in conjunction with the design of both hydrolytically stable high potential quinones and new purine-like reductive alkylators.These systems consist of a benzoquinone ring bearing two fused pyrimidin-4(3H)-one rings.The fused pyrimidinone rings serve to protect 1 and 2 from hydrolysis as well as to raise quinone redox potentials by stabilizing the hydroquinones with internal hydrogen bonds (65 mV increase per hydrogen bond).Synthesis of 1 and 2 involved pyrimidinone ring annelation to a 2,5-diamino-3-nitroterephthalic acid derivative and to a 2,4-diamino-1,5-dicarboxy-3-nitrobenzene derivative, respectively.The synthetic studies provided insights into the electronic effects of nitro and amino groups on the annelation process.