115827-18-4

Basic information

• Product Name: 2-Propanol, 3-amino-1,1-diethoxy-
• Synonyms: 2-Propanol, 3-amino-1,1-diethoxy-
• CAS NO: 115827-18-4
• Molecular Formula: C₇H₁₇NO₃
• Molecular Weight: 163.21
• Mol File: 115827-18-4.mol

Chemical Properties

• Melting Point: 43 °C
• Boiling Point: 120-121 °C
• Appearance: /
• Density: 1.028±0.06 g/cm3(Predicted)
• PKA: 12.51±0.35(Predicted)
• CAS DataBase Reference: 2-Propanol, 3-amino-1,1-diethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 3-amino-1,1-diethoxy-(115827-18-4)
• EPA Substance Registry System: 2-Propanol, 3-amino-1,1-diethoxy-(115827-18-4)

Safety Data

• Hazardous Substances Data: 115827-18-4(Hazardous Substances Data)

Upstream product

• 18295-36-8 1,1-diethoxy-3-nitro-propan-2-ol 
• 13269-77-7 2,3-epoxy-1,1-diethoxypropane 
• 115827-08-2 (D,L)-3-azido-2-hydroxypropanal diethyl acetal 
• 60-29-7 diethyl ether 
• 5344-23-0 diethoxyacetaldehyde 

Downstream Products

• 182680-54-2 3-benzyloxycarbonylamino-2-hydroxy-propionaldehyde diethyl acetal 

Relevant articles and documents

3-Amino-2-hydroxy-propionaldehyde and 3-amino-1-hydroxypropan-2-one derivatives: New classes of aminopeptidase inhibitors

3-Amino-2-hydroxy-propionaldehydes [H2NCH(R)CHOHCHO with R = H, i-Bu, CH2Ph] were designed as metalloaminopeptidase inhibitors based on the metal active site chelation concept. These compounds were found to be micromolar inhibitors of aminopeptidase-M (AP-M, EC 3.4.11.2) with potencies similar to bestatin (K(i) = 3.5 μM). Notably, compound 5a (R = H) is a selective inhibitor of AP-M (K(i) = 7 μM) with respect to cytosolic leucine aminopeptidase (LAPc, EC 3.4.11.1) (K(i) = 385 μM). However, due to their easy oligomerization, these compounds are of low practical value. In contrast, the corresponding isomeric 3-amino-1-hydroxy-propan-2-one derivatives [H2NCH(R)COCH2OH with R = H, i-Bu, CH2Ph, i-Pr, CH2Biph] are well defined structures. These hydroxymethylketones also exhibit micromolar affinities on AP-M. Compound 6c (R = CH2Ph) was the most potent (K(i) = 1 μM). Selectivity studies of 6a (R = H) and 6b (R = i-Bu) show a preference for AP-M. Compound 6a is moderately active on AP-M (K(i) = 25 μM) and inactive on LAPc. This new class of inhibitors is proposed to bind as bidentates, analogous to hydroxamates.

3-azido compound

A new and practical method for synthesizing heterocyclic polyhydroxylated alkaloids using enzymatic aldol condensation and catalytic intramolecular reductive amination is disclosed.

Fructose 1,6-Diphosphate Aldolase Catalyzed Stereoselective Synthesis of C-Alkyl and N-Containing Sugars: Thermodynamically Controlled C-C Bond Formations.

Fructose 1,6-diphosphate aldolase catalyzed aldol condensations have been used in syntheses of several new N-containing and C-alkyl sugars on 4-20 mmol scales.The enzyme is highly specific for dihydroxyacetone phosphate as donor but accepts a number of achiral and chiral aldehydes (both D and L isomers) as acceptors.Due to the reversible nature of the aldol reaction, a thermodynamically controlled approach was employed for the syntheses in which racemic aldehydes were used as substrates and thermodynamically more stable products were preferentially produced.