- STRAD-BINDING AGENTS AND USES THEREOF
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Disclosed herein, inter alia, are compounds for binding STRAD pseudokinase and uses thereof.
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Paragraph 1054-1056
(2021/08/06)
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- Synthetic method of 2-oxetane derivative
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The invention relates to the field of medical intermediates, especially to a synthetic method of a 2-oxetane derivative. A synthetic route as shown in the formula (I) is adopted. In the formula (I), Ris a leaving group and X is halogen. By the use of a ch
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Paragraph 0038; 0039; 0040
(2019/01/08)
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- COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
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Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
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Page/Page column 250; 251
(2017/09/15)
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- An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer
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A number of indole-3-glyoxylamides have previously been reported as tubulin polymerization inhibitors, although none has yet been successfully developed clinically. We report here a new series of related compounds, modified according to a strategy of redu
- Colley, Helen E.,Muthana, Munitta,Danson, Sarah J.,Jackson, Lucinda V.,Brett, Matthew L.,Harrison, Joanne,Coole, Sean F.,Mason, Daniel P.,Jennings, Luke R.,Wong, Melanie,Tulasi, Vamshi,Norman, Dennis,Lockey, Peter M.,Williams, Lynne,Dossetter, Alexander G.,Griffen, Edward J.,Thompson, Mark J.
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p. 9309 - 9333
(2015/12/23)
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- ARYL GLYCOSIDE COMPOUND, PREPARATION METHOD AND USE THEREOF
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Disclosed are an aryl glycoside compound as represented by formula I or formular I′, a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential.
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Paragraph 0156; 0157
(2014/01/07)
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- ARYL GLYCOSIDE COMPOUND, PREPARATION METHOD AND USE THEREOF
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Disclosed are an aryl glycoside compound as represented by formula I or formular I', a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof. The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential.
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Paragraph 0103; 0104
(2014/01/09)
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- NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
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The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (I). wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, formula (II). wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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Page/Page column 124-125
(2009/06/27)
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- NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
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The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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Page/Page column 49-50
(2008/06/13)
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- CONCERTED VERSUS STEPWISE PROCESSES IN ELIMINATIVE FISSION OF OXACYCLES
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2-Phenylsulphonylmethyloxetan (2a) has been synthesised and the kinetics of base-promoted eliminative ring fission have been determined.The results show, by comparison with the behaviour of related substrates studied previously, that (i) the 3-ring,:4-rin
- Griffiths, Gwerydd,Stirling, Charles J. M.
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-
- Synthesis of Simple Oxetanes Carrying Reactive 2-Substituents
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Ring-expansion of substituted epoxides using dimethyloxosulphonium methylide provides a convenient route to oxetanes carrying reactive 2-substituents that are capable of further modification.
- Fitton, Alan O.,Hill, John,Jane, David E.,Millar, Ross
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p. 1140 - 1142
(2007/10/02)
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