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1158728-80-3

4'-C-azido-2'-deoxy-2'-fluoro-uridine is a chemical compound belonging to the class of nucleoside analogues. It is a modified form of uridine, characterized by the presence of an azido group at the 4'-carbon position and a fluoro group at the 2'-carbon position. This unique structural modification endows it with potential antiviral and anticancer activities, as well as applications in nucleic acid labeling and bioconjugation studies. As a promising candidate in medicinal chemistry and drug discovery, 4'-C-azido-2'-deoxy-2'-fluoro-uridine is of significant interest for its distinctive properties and potential biological impacts.

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  • 1158728-80-3 Structure

  • Basic information

    1. Product Name: 4'-C-azido-2'-deoxy-2'-fluoro-uridine
    2. Synonyms: 4'-C-azido-2'-deoxy-2'-fluoro-uridine;1-[(2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
    3. CAS NO:1158728-80-3
    4. Molecular Formula: C9H10FN5O5
    5. Molecular Weight: 287.2046032
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 1158728-80-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4'-C-azido-2'-deoxy-2'-fluoro-uridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4'-C-azido-2'-deoxy-2'-fluoro-uridine(1158728-80-3)
    11. EPA Substance Registry System: 4'-C-azido-2'-deoxy-2'-fluoro-uridine(1158728-80-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1158728-80-3(Hazardous Substances Data)

1158728-80-3 Usage

Uses

Used in Pharmaceutical Industry:
4'-C-azido-2'-deoxy-2'-fluoro-uridine is used as a nucleoside analogue for its potential antiviral and anticancer activities. 4'-C-azido-2'-deoxy-2'-fluoro-uridine's unique structural features allow it to interfere with viral replication and cancer cell proliferation, making it a valuable asset in the development of new therapeutic agents.
Used in Biotechnology Industry:
In the biotechnology sector, 4'-C-azido-2'-deoxy-2'-fluoro-uridine serves as a key component in nucleic acid labeling. Its incorporation into nucleic acid sequences enables the tracking and detection of specific genetic material, which is crucial for various molecular biology techniques and research applications.
Used in Research and Development:
4'-C-azido-2'-deoxy-2'-fluoro-uridine is utilized in bioconjugation studies, where it can be linked to other molecules to create hybrid compounds with novel properties. This application is vital for the advancement of targeted drug delivery systems and the development of new diagnostic tools in medical research.
Overall, 4'-C-azido-2'-deoxy-2'-fluoro-uridine's multifaceted applications across different industries underscore its importance in the fields of medicine, biotechnology, and scientific research, highlighting its potential to contribute to innovative solutions in healthcare and life sciences.

Check Digit Verification of cas no

The CAS Registry Mumber 1158728-80-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,8,7,2 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1158728-80:
(9*1)+(8*1)+(7*5)+(6*8)+(5*7)+(4*2)+(3*8)+(2*8)+(1*0)=183
183 % 10 = 3
So 1158728-80-3 is a valid CAS Registry Number.

1158728-80-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4'-azido-2'-deoxy-2'-fluorouridine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1158728-80-3 SDS

1158728-80-3Upstream product

1158728-80-3Downstream Products

1158728-80-3Relevant articles and documents

4'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF EBOLA VIRUS RNA REPLICATION

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Paragraph 0329, (2016/09/12)

The application discloses compounds of Formula I wherein the variable substituents are as defined herein. The compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I are useful for the treatment of diseases mediated by Filoviruses such as Ebolavirus.

3-methyl uridine and 4-methyl cytidine nucleoside compound, synthetic method and its pharmaceutical use

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Paragraph 0021; 0044, (2016/10/08)

The invention discloses a 3-methyluridine and 4-methylcytidine nucleosides compound and a synthesis method and pharmaceutical application thereof, belonging to the field of medicinal chemistry. The compound has a structural formula as shown in the specification. The compound has the effects of simultaneously modifying sugar rings and basic groups, increasing the activity of the compound and reducing the toxicity, provides a good application prospect for development of like medicines and can be applied to preparation of anti-HBV (Hepatitis B virus) medicines. The synthesis method is simple and feasible and provides conditions for mass synthesis of the compound.

Azido nucleosides and nucleotide analogs

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Page/Page column 96; 98, (2016/06/13)

Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS

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Page/Page column 64-65, (2009/06/27)

Embodiments of the invention are to compounds of formulae (A), (A'), methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention aur 2 ', 4 ' -substituted nucleoside compounds useful for the treat

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