Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors
The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C9 inh
Gilbert, Eric J.,Zhou, Guowei,Wong, Michael K.C.,Tong, Ling,Shankar, Bandarpalle B.,Huang, Chunli,Kelly, Joseph,Lavey, Brian J.,McCombie, Stuart W.,Chen, Lei,Rizvi, Razia,Dong, Youhao,Shu, Youheng,Kozlowski, Joseph A.,Shih, Neng-Yang,Hipkin, R. William,Gonsiorek, Waldemar,Malikzay, Asra,Lunn, Charles A.,Favreau, Len,Lundell, Daniel J.
scheme or table
p. 608 - 611
(2010/05/02)
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