Method for Ir/f-amphox high-efficiency synthesis of chiral α- C-amino alcohol by virtue of catalytic oxidation 1,2- of P-aminoketone by using one-aminoketone
The invention discloses a method for efficiently synthesizing chiral 1,2-amino alcohol by catalyzing alpha-aminoketone through Ir/f-amphox. A ligand f-amphox used by the method can be more easily synthesized; the reaction has the characteristics of enanti
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Paragraph 0073-0078
(2020/01/03)
Method for preparing of L-phenylephrine hydrochloride
The present invention relates to an improved process for preparing L-phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the key step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as the catalyst system.
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(2008/06/13)
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