SPIROCYCLIC PIPERIDINE MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF
Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.
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(2021/07/02)
Efficient synthesis of 5-alkoxy-(3r)-hydroxy-2,3-dihydrospiro[indene-1, 4?-piperidines]: A novel scaffold for renin inhibitors
We report herein, an efficient synthetic method for the preparation of a 5-alkoxy-(3R)-hydroxy-2,3-dihydrospiro[indene-1,4-piperidines] scaffold using a regioselective intermolecular ?reaction and a stereoselective reduction as key steps. Compound 2, base