1160949-99-4

Basic information

• Product Name: 3-BroMoquinolin-7-ol
• Synonyms: 3-BroMoquinolin-7-ol;3-bromo-1H-quinolin-7-one
• CAS NO: 1160949-99-4
• Molecular Formula: C9H6BrNO
• Molecular Weight: 224.05404
• Mol File: 1160949-99-4.mol

Chemical Properties

• Boiling Point: 348.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.705±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.54±0.40(Predicted)
• CAS DataBase Reference: 3-BroMoquinolin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMoquinolin-7-ol(1160949-99-4)
• EPA Substance Registry System: 3-BroMoquinolin-7-ol(1160949-99-4)

Safety Data

• Hazardous Substances Data: 1160949-99-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
3-Bromoquinolin-7-ol is utilized as an intermediate in organic synthesis for the production of other chemical compounds. Its unique structure allows it to serve as a building block, contributing to the creation of a variety of molecules with diverse applications.
Used in Pharmaceutical Applications:
3-Bromoquinolin-7-ol is studied for its potential biological activities and pharmacological properties. While the specific applications in this field are still under investigation, its unique structural features suggest it may have roles in the development of new drugs or therapeutic agents.
Used in Research and Development:
In the scientific community, 3-Bromoquinolin-7-ol is employed as a subject of study to explore its potential applications in various areas. This includes understanding its interactions with biological systems and its capacity to be modified or combined with other compounds to create new pharmaceuticals or materials.

Upstream product

• 1344046-07-6 7-amino-3-bromoquinoline 
• 613-51-4 7-nitroquinoline 
• 580-20-1 quinolin-7-ol 

Relevant articles and documents

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

Synthesis method of 3-bromine-7-hydroxyquinoline

The invention provides a synthesis method of 3-bromine-7-hydroxyquinoline. The synthesis method of the 3-bromine-7-hydroxyquinoline includes the following steps that 1, 7-hydroxyquinoline is dissolvedin solvent, trifluoromethanesulfonic anhydride is added, and low temperature reaction is carried out to obtain quinoline-7-trifluoromethanesulfonate, wherein the molar ratio of the 7-hydroxyquinolineto the trifluoromethanesulfonic anhydride is 1:(1-1.5); 2, the quinoline-7-trifluoromethanesulfonate obtained in step 1 is dissolved in solvent, N-bromosuccinimide is added, and after reaction, 3-bromoquinoline-7-trifluoromethanesulfonate is obtained; 3, the 3-bromoquinoline-7-trifluoromethanesulfonate obtained in step 2 is hydrolyzed under an alkaline condition to obtain the 3-bromine-7-hydroxyquinoline. According to the synthesis method of the 3-bromine-7-hydroxyquinoline, the raw materials are stable and non-toxic, the synthesis technology is simple, and the yield is high.