1161720-69-9Relevant articles and documents
Development of 1,2,3-triazole-based sphingosine kinase inhibitors and their evaluation as antiproliferative agents
Corvino, Angela,Rosa, Roberta,Incisivo, Giuseppina Maria,Fiorino, Ferdinando,Frecentese, Francesco,Magli, Elisa,Perissutti, Elisa,Saccone, Irene,Santagada, Vincenzo,Cirino, Giuseppe,Riemma, Maria Antonietta,Temussi, Piero A.,Ciciola, Paola,Bianco, Roberto,Caliendo, Giuseppe,Roviezzo, Fiorentina,Severino, Beatrice
, (2017/11/16)
Two series of N-(aryl)-1-(hydroxyalkyl)pyrrolidine-2-carboxamides (2a-2g and 3a-3g) and 1,4-disubstituted 1,2,3-triazoles (5a-5h and 8a-8h) were synthesized. All the compounds, containing a lipophilic tail and a polar headgroup, were evaluated as sphingos
Synthesis and analgesic evaluation of a series of proline-typed spiro cyclic quaternary ammoniums
Lin, Songwen,Wang, Na,Zhao, Shuo,Sun, Qi,Zhang, Weiwei,Ye, Jia,Cheng, Tieming,Li, Runtao
, p. 862 - 869 (2014/03/21)
A series of proline derivated spirocyclic quaternary ammoniums were synthesized and evaluated via in vivo analgesic activities. Compounds 9a showed the best analgesic effect with 84 % inhibition in mice. These compounds showed only micromolar Ki value by in vitro α7 nAChR binding test, which may indicate the form of active metabolite play a role in their in vitro analgesic activities.