116206-41-8

Basic information

• Product Name: 1H-2-Benzopyran-1-one,3,4-dihydro-3-hydroxy-(9CI)
• Synonyms: 1H-2-Benzopyran-1-one,3,4-dihydro-3-hydroxy-(9CI)
• CAS NO: 116206-41-8
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.15802
• Product Categories: PHENYL
• Mol File: 116206-41-8.mol

Chemical Properties

• Boiling Point: 396.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.359±0.06 g/cm3(Predicted)
• PKA: 12.26±0.20(Predicted)
• CAS DataBase Reference: 1H-2-Benzopyran-1-one,3,4-dihydro-3-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-2-Benzopyran-1-one,3,4-dihydro-3-hydroxy-(9CI)(116206-41-8)
• EPA Substance Registry System: 1H-2-Benzopyran-1-one,3,4-dihydro-3-hydroxy-(9CI)(116206-41-8)

Safety Data

• Hazardous Substances Data: 116206-41-8(Hazardous Substances Data)

Upstream product

• 95-13-6 1-indene 
• 73258-06-7 1,4-epoxy-4,5-dihydro-1H-2,3-benzodioxepin 

Relevant articles and documents

One-pot synthesis of 3,4-dihydro-3-hydroxyisochroman-1-one and evaluation of acetal derivatives as antibacterial and antifungal agents

A one-pot synthesis of 3,4-dihydro-3-hydroxyisochroman-1-one (lactol) 3 by oxidation of indene using tungstic acid-hydrogen peroxide is reported. The synthesized lactol was converted into acetal derivatives 5a-h, which were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes (Gram-positive), Escherichia coli, Pseudomonas aeruginosa (Gram-negative) strains, and antifungal activity against Candida albicans and Aspergillus niger by broth dilution method. The compounds show potent activity against S. aureus in comparison with ampicillin and exhibit modest antifungal activity.

18O-tracer studies of Fe(II)-induced decomposition of 1,2,4-trioxolanes (ozonides) derived from cyclopentenes and indenes. Inner-sphere electron transfer reduction of the peroxide linkage

Fe(II)-induced decomposition of 1,2,4-trioxolanes (ozonides) 1 and 2 is studied in detail. The inner-sphere electron transfer reduction, which is sensitive to steric effects, is proposed to be a reasonable mechanism for the peroxide decomposition, i.e., the selective generation of one of the two possible Fe(III)-complexed oxy radicals. The fate of the oxy radical species is revealed in detail by using 18O-tracer studies in the reduction of 18O-labeled ozonides 1a and 2a, in which the ethereal oxygens are labeled by 18O atom (18O, 77%) and also by the reduction in the presence of H218O (18O, 10%). The results of the 18O-tracer studies are consistent with the regioselective generation of the Fe(III)-complexed oxy radical species.

PROSTANOIDS. SYNTHESIS OF &α-PENTANORBENZO ANALOGS OF PROSTAGLANDINS

The α-pentanorbenzo analogs of prostaglandins were synthesized from o-formylphenylacetic acid, which was obtained by the ozonization of indene under specific conditions.