cas 1163135-96-3, BiMatoprost IMpurity III

The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.

Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

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Chemical Properties

Boiling Point: 626.7±55.0 °C(Predicted)

Density: 1.142±0.06 g/cm3(Predicted)

Solubility:Dichloromethane (Slightly), Methanol (Slightly)

Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere

PKA: 14.42±0.70(Predicted)

PSA: 90.12000

LogP: 4.19540

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