116369-23-4

Basic information

• Product Name: 2-fluoro-3-trifluoromethoxy aniline
• Synonyms: 2-fluoro-3-trifluoromethoxy aniline;2-Fluoro-5-(trifluoromethoxy)aniline, JRD, 97%;2-Fluoro-5-(trifluoromethoxy)aniline 99%;3-Amino-alpha,alpha,alpha,4-tetrafluoroanisole;2-Fluoro-5-(trifluoromethoxy)
• CAS NO: 116369-23-4
• Molecular Formula: C₇H₅F₄NO
• Molecular Weight: 195.11
• Mol File: 116369-23-4.mol

Chemical Properties

• Boiling Point: 185.5 °C at 760 mmHg
• Flash Point: 66 °C
• Appearance: /
• Density: 1.431 g/cm³
• Vapor Pressure: 0.54mmHg at 25°C
• Refractive Index: 1.4485
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.97±0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 2-fluoro-3-trifluoromethoxy aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-3-trifluoromethoxy aniline(116369-23-4)
• EPA Substance Registry System: 2-fluoro-3-trifluoromethoxy aniline(116369-23-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: 6.1
• Hazardous Substances Data: 116369-23-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-3-trifluoromethoxy aniline is used as a key intermediate in the synthesis of novel benzimidazoles, which are potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. These inhibitors play a crucial role in the development of targeted therapies for various diseases, including cancer.
Used in Chemical Synthesis Studies:
2-Fluoro-3-trifluoromethoxy aniline is also utilized as a coupling agent in chemical synthesis, enabling the formation of new compounds with potential applications in various fields. Its unique structural properties make it a valuable component in the development of innovative chemical entities.

InChI:InChI=1/C7H5F4NO/c8-5-2-1-4(3-6(5)12)13-7(9,10)11/h1-3H,12H2

Upstream product

• 352-67-0 1-fluoro-4-(trifluoromethoxy)benzene 
• 123572-62-3 4-fluoro-2-nitro-1-trifluoromethoxy-benzene 
• 124170-06-5 1-fluoro-2-nitro-4-(trifluoromethoxy)benzene 

Downstream Products

• 1346237-13-5 2,2,2-trifluoro-N-(5-fluoro-2-trifluoromethoxy-phenyl)-acetamide 
• 1208977-11-0 (2-fluoro-5-trifluoromethoxy-phenyl)-carbamic acid ethyl ester 
• 1374892-14-4 (R)-4-[5-(5-fluoro-4'-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-ylcarbamoyl)pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert butyl ester 
• 1433281-07-2 (R)-4-[5-(5-fluoro-4'-{2-[(2S,4S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-4-methyl-pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1433280-23-9 (R)-4-[5-(4-bromo-2-fluoro-5-trifluoromethoxy-phenylcarbamoyl)-pyridin-2-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1374892-23-5 (2S,5R)-4-[5-(4-bromo-2-fluoro-5-trifluoromethoxy-phenylcarbamoyl)-pyridin-2-yl]-2,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1374892-24-6 N-(4-bromo-2-fluoro-5-trifluoromethoxy-phenyl)-6-fluoro-nicotinamide 
• 1374892-13-3 {(S)-1-[(S)-2-(4-{5'-fluoro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethoxy-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester 

Relevant articles and documents

DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-1H-INDOL-3-YL]-METHANONES

The present invention extends to the compound of formula I: or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective