- A 2, 5 - difluoro -4 - nitro benzoic acid (by machine translation)
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The invention discloses a 2, 5 - difluoro - 4 - nitro-benzoic acid industrial preparation method. The 2, 5 - difluoro - 4 - nitro-benzoic acid industrial preparation method, the initial raw materials to the difluoro, through the bromo, nitration, carbonitriding, the hydrolysis of the four-step reaction synthesis of 2, 5 - difluoro - 4 - nitro-benzoic acid. The got in the course of 2, 5 - difluoro - 4 - nitrobenzoic acid as white powdery solid, purity 98.5%, each step the raw material conversion rate respectively reaches 100%, the total yield of the whole process 44.6%. (by machine translation)
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Paragraph 0009; 0012; 0013; 0016
(2019/03/08)
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- Quinazoline antifolate thymidylate synthase inhibitors: Difluoro- substituted benzene ring analogues
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The synthesis of a series of new C2-methyl-N10-alkylquinazoline-based thymidylate synthase (TS) inhibitors containing difluorinated p-aminobenzoate rings is described. Derivatives of the N10-propargyl and N10- m
- Thornton,Jackman,Marsham,O'Connor,Bishop,Calvert
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p. 2321 - 2327
(2007/10/02)
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