116529-86-3

Basic information

• Product Name: 8-methyl-6-nitroquinoline
• Synonyms: 8-methyl-6-nitroquinoline
• CAS NO: 116529-86-3
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18272
• Mol File: 116529-86-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-methyl-6-nitroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methyl-6-nitroquinoline(116529-86-3)
• EPA Substance Registry System: 8-methyl-6-nitroquinoline(116529-86-3)

Safety Data

• Hazardous Substances Data: 116529-86-3(Hazardous Substances Data)

Upstream product

• 56-81-5 glycerol 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Downstream Products

• 857602-58-5 4-chloro-2-(8-methyl-[6]quinolylamino)-benzoic acid 
• 1609646-73-2 N-((6-nitroquinolin-8-yl )methyl)-4-(trifluoromethyl)benzenesulfonamide 

Relevant articles and documents

Rh(iii)-Catalyzed mild straightforward synthesis of quinoline-braced cyclophane macrocycles: Via migratory insertion

An efficient Rh(iii)-catalyzed straightforward strategy is developed for the synthesis of quinoline braced cyclophane macrocycles via methyl (sp3) C-H functionalization. The method is mild, simple and regioselective with various ring sizes and has good fu

Rh(iii)-Catalyzed straightforward arylation of 8-methyl/formylquinolines using diazo compounds

A straightforward Rh(iii)-catalyzed general strategy was developed for the introduction of naphthol/phenol moieties to the C(sp3)-H bond of 8-methylquinoline using diazonaphthalen-2(1H)-ones/quinone diazides. The developed method was further extended towards the arylation of 8-formylquinolines to accomplish diarylketone derivatives. The method is simple, relatively rapid, and chemo and regioselective with a wide scope and functional group tolerance. The synthetic utility was established through gram-scale synthesis and biologically active molecule construction.

Rhodium(III)-catalyzed intermolecular amidation with azides via C(sp 3)-H functionalization

The amidation reactions of 8-methylquinolines with azides catalyzed by a cationic rhodium(III) complex proceed efficiently to give quinolin-8- ylmethanamine derivatives in good yields via C(sp3)-H bond activation under external oxidant-free conditions. A catalytically competent five-membered rhodacycle has been isolated and characterized, revealing a key intermediate in the catalytic cycle.

Synthesis of mono-substituted derivatives of 6-aminoquinoline

Several 6-aminoquinoline derivatives, which could be used in drug design, have been synthesized. The reaction conditions were comparatively studied, and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction. The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.

FUNGICIDAL 2-ALKYLTHIO-2-QUINOLINYLOXY-ACETAMIDE DERITVATIVES

Fungicidal compounds of the general formula (I), wherein the substituents are as defined in claim1.

Catalytic aerobic oxidation of substituted 8-methylquinolines in Pd II-2,6-pyridinedicarboxylic acid systems

The ability of PdII complexes derived from 2,6- pyridinedicarboxylic acids to catalyze homogeneous regioselective aerobic oxidation of 5- and 6-substituted 8-methylquinolines in AcOH-Ac2O solution to produce corresponding 8-quinolylm