A short, elegant, and high yielding synthesis of ravoconazole is presented. The key step of this synthesis is an enantioselective palladium-catalyzed chiral zinc-allene addition reaction. The starting materials are 2-chloro-1-(2,4-difluorophenyl)-ethanone and (R)-4-phenylbutyn-2-ol obtained from enzymatic resolution of its racemate. Copyright Taylor & Francis Group, LLC.
Xu, Lin,Muller, Marc R.,Yu, Xiong,Zhu, Bao-Quan
experimental part
p. 1611 - 1625
(2009/10/17)
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