3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists
Replacement of a quinoline with an imidazo[1,2-a]pyridine in a series of liver X receptor (LXR) agonists incorporating a [3-(sulfonyl)aryloxyphenyl] side chain provided high affinity LXR ligands 7. In functional assays of LXR activity, good agonist potency and efficacy were found for several analogs.
Singhaus, Robert R.,Bernotas, Ronald C.,Steffan, Robert,Matelan, Edward,Quinet, Elaine,Nambi, Ponnal,Feingold, Irene,Huselton, Christine,Wilhelmsson, Anna,Goos-Nilsson, Annika,Wrobel, Jay
scheme or table
p. 521 - 525
(2010/04/26)
IMIDAZO [1,2-A] PYRIDINE COMPOUNDS
This invention relates generally to imidazo [1,2-a] pyridine-based modulators of Liver X receptors (LXRs) and related methods.
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Page/Page column 93-94
(2009/08/14)
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