1169699-63-1

Basic information

• Product Name: N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide
• Synonyms: N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide;2-Chloro-N-[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]acetamide
• CAS NO: 1169699-63-1
• Molecular Formula: C15H21ClN2O2
• Molecular Weight: 296.79244
• Mol File: 1169699-63-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide(1169699-63-1)
• EPA Substance Registry System: N-((1-benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetaMide(1169699-63-1)

Safety Data

• Hazardous Substances Data: 1169699-63-1(Hazardous Substances Data)

Usage

Uses

Used in Medical Applications:
N-((1-Benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetamide is used as a local anesthetic for its ability to block sodium ion channels, which are essential for nerve impulse initiation and conduction. This results in the temporary numbing of a specific body area, making it suitable for surgical procedures and childbirth, particularly in epidural anesthesia.
Used in Surgical Procedures:
N-((1-Benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetamide is used as a long-acting anesthetic to provide pain relief during and after surgeries. Its advantage over other anesthetics lies in its prolonged effect, which allows for extended periods of analgesia.
Used in Childbirth (Epidural Anesthesia):
N-((1-Benzyl-4-hydroxypiperidin-4-yl)Methyl)-2-chloroacetamide is used as an epidural anesthetic during childbirth to provide pain relief to the mother while allowing her to remain conscious and actively participate in the birthing process. Its long-lasting effect ensures continuous pain management throughout labor.

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 23804-68-4 4-(aminomethyl)-1-benzyl-4-hydroxypiperidine 
• 79-04-9 chloroacetyl chloride 
• 19867-34-6 N-benzyl-1-oxa-6-azaspiro[2,5]-octane 

Downstream Products

• 1023595-11-0 tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate 

Relevant articles and documents

Spirocyclic derivatives

The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease, disorder or condition ameliorated by inhibition of a dopamine transporter); and methods of treating patients with such compounds; wherein R1, R2, R3, R4, R5, R6, R9, R10, Q, X, Y, Z, A, L, B, m, n and p are as defined herein.

2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD)

The present invention provides compounds of formula (I) and in particular 2-[bis(4-fluorophenyl)methyl]-2,7- diazaspiro[4.5]decan-10-one derivatives and related compounds as inhibitors of human dopamine-active-transporter (DAT) protein for the treatment of sexual dysfunction, affective disorders, anxiety, depression, chronic fatigue, Tourette syndrome, Angelman syndrome, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), obesity, pain, obsessive-compulsive disorder, movement disorders, CNS disorders, sleep disorders, narcolepsy, conduct disorder, substance abuse (including smoking cessation), eating disorders, and impulse control disorders.