116990-44-4

Basic information

• Product Name: Thiazolo[5,4-c]pyridine-2-thiol
• Synonyms: Thiazolo[5,4-c]pyridine-2-thiol;[1,3]Thiazolo[5,4-c]pyridine-2(1H)-thione
• CAS NO: 116990-44-4
• Molecular Formula: C6H4N2S2
• Molecular Weight: 168.23936
• Mol File: 116990-44-4.mol

Chemical Properties

• Melting Point: >290 °C
• Boiling Point: 343.9±34.0 °C(Predicted)
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• PKA: 8.45±0.20(Predicted)
• CAS DataBase Reference: Thiazolo[5,4-c]pyridine-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolo[5,4-c]pyridine-2-thiol(116990-44-4)
• EPA Substance Registry System: Thiazolo[5,4-c]pyridine-2-thiol(116990-44-4)

Safety Data

• Hazardous Substances Data: 116990-44-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[5,4-c]pyridine-2-thiol is used as a building block in the synthesis of various organic compounds for drug discovery. Its unique structure and properties may contribute to the development of new pharmaceutical agents with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, Thiazolo[5,4-c]pyridine-2-thiol may be utilized as a component in the development of novel agrochemicals, such as pesticides or herbicides, due to its potential biological activity and chemical properties.
Used in Materials Science:
Thiazolo[5,4-c]pyridine-2-thiol's unique structure and properties also make it a valuable compound in materials science. It can be used as a component in the development of new materials with specific properties, such as conductivity, stability, or reactivity, for various applications in different industries.
Overall, Thiazolo[5,4-c]pyridine-2-thiol is a versatile chemical compound with diverse potential applications across different industries, including pharmaceuticals, agrochemicals, and materials science, due to its unique molecular structure and properties.

Downstream Products

• 1190927-31-1 2-Chloro[1,3]thiazolo[5,4-c]pyridine 

Relevant articles and documents

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists

In search for a new lead of non-imidazole histamine H3-receptor antagonists, a series of 1[(2-thiazolopyridine)-4-n-propyl]piperazines, the analogous 1-[(2-oxazolopyridine)-4-npropyl]piperazines, 1-[(2-benzothiazole)-4- n-propyl]piperazine and 1-[(2-benzooxazole)4-n-propyl]piperazine were prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). It appeared that by comparison of homologous pairs the thiazolo derivatives have slightly higher activity than their oxazolo analogues. The most potent compound of these series is the 1-(2-thiazolo[4,5-c]pyridine)-4-n-propylpiperazine (3c) with pA2 = 7.25 (its oxazole analogue (4g) showed pA2 = 6.9). The structure-activity relationships for compounds with various positions of the nitrogen in the benzene ring for the thiazoles compared with oxazoles are discussed.