117048-15-4Relevant articles and documents
N1-hydroxylated derivatives of chlorpropamide and its analogs as inhibitors of aldehyde dehydrogenase in vivo
Lee,Elberling,Nagasawa
, p. 3641 - 3647 (2007/10/02)
Certain (arylsulfonyl)urea hypoglycemic drugs exemplified by chlorpropamide (CP) are known to interact pharmacologically with alcohol (ethanol) to elicit a chlorpropamide-alcohol flushing (CPAF) reaction that is reminiscent of the disulfiram-ethanol react
N1-alkyl-substituted derivatives of chlorpropamide as inhibitors of aldehyde dehydrogenase.
Nagasawa,Elberling,DeMaster,Shirota
, p. 1335 - 1340 (2007/10/02)
On the basis of an earlier observation that the N1-ethyl derivative of the hypoglycemic agent chlorpropamide (CP) inhibited aldehyde dehydrogenase (AlDH) in rats without producing hypoglycemia, we undertook a structure-activity study to assess the effect