- INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.
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Page/Page column 68
(2015/07/15)
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- INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.
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Page/Page column 69
(2015/07/15)
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- NOVEL RING TRANSFORMATIONS OF PYRAZINES BY INTRAMOLECULAR DIELS-ALDER REACTIONS
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Pyrazines carrying the ω-alkyne side-chain -XCH2CH2CH, (X = O,N,S,SO,SO2,C(CN)2) undergo on heating an intramolecular Diels-Alder reaction.Pyrazines with the electron donating atom (O,N or S) in the side-chain afford -fused pyridines as main products, whereas (3-butynylsulfinyl)pyrazine and (3-butynylsulfonyl)pyrazine are exclusively converted into -fused pyridines.A -fused pyridine is also the major product in the reaction of 2,5-bis(1,1-dicyano-4-pentynyl)pyrazine.
- De Bie, D.A.,Ostrowicz, A.,Geurtsen, G.,Van Der Plas, H.C.
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p. 2977 - 2984
(2007/10/02)
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