Umpolung of Carbonyl Groups as Alkyl Organometallic Reagent Surrogates for Palladium-Catalyzed Allylic Alkylation
Palladium-catalyzed allylic alkylation of nonstabilized carbon nucleophiles is difficult and remains a major challenge. Reported here is a highly chemo- and regioselective direct palladium-catalyzed C-allylation of hydrazones, generated from carbonyls, as a source of umpolung unstabilized alkyl carbanions and surrogates of alkyl organometallic reagents. Contrary to classical allylation techniques, this umpolung reaction utilizes hydrazones prepared not only from aryl aldehydes but also from alkyl aldehydes and ketones as renewable feedstocks. This strategy complements the palladium-catalyzed coupling of unstabilized nucleophiles with allylic electrophiles by providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.
General Approach to Highly Functionalized Benzylic Organometallics of Zinc and Copper
A general synthesis of highly functionalized benzylic zinc organometallics is described.The corresponding copper derivatives, formed by a transmetalation with CuCN*2LiCl, react in high yields with allylic halides, enones, acyl chlorides, and aldehydes.
Berk, Scott C.,Knochel, Paul,Yeh, Ming Chang P.
p. 5789 - 5791
(2007/10/02)
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