1175536-50-1

Basic information

• Product Name: (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Mesylate
• Synonyms: (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Mesylate;(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol methanesulfonate;Efinaconazole Related Impurity 7 Mesylate;1-[(2R,3R)-2-(2,4-difluorophenyl)-2,3-dihydroxybutyl]-1 H-[1,2,4]triazole methanesulfonate salt;(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol with methanesulfonate;(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol methanesulfonate
• CAS NO: 1175536-50-1
• Molecular Formula: CH₄O₃S*C₁₂H₁₃F₂N₃O₂
• Molecular Weight: 347.3377064
• EINECS: -0
• Mol File: 1175536-50-1.mol

Chemical Properties

• Melting Point: 173.5-174.5℃
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Mesylate(1175536-50-1)
• EPA Substance Registry System: (2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol Mesylate(1175536-50-1)

Safety Data

• Hazardous Substances Data: 1175536-50-1(Hazardous Substances Data)

Upstream product

• 288-88-0 1,2,4-Triazole 
• 75-75-2 methanesulfonic acid 
• 1774-47-6 trimethylsulfoxonium iodide 
• 127001-03-0 (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone 

Downstream Products

• 124627-86-7 1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole 

Relevant articles and documents

A preparation method of the midbody sets up lucky Kang Zuo (by machine translation)

The invention relates to the field of pharmaceutical technology, in particular to a method of preparing intermediates of sets up lucky Kang Zuo, comprising the following steps: D, L - methyl lactate, morpholine, 3, 4 - methoxychroman reaction, with 2, 4 - difluoro bromobenzene reagent reaction to obtain compound III format; compound III in the catalyst under the catalysis of the B L - menthol and triphenylphosphine, by the asymmetric kohl Chaikefusiji reaction to obtain the chiral compound IV; compound IV with 1, 2, 4 - triazole reaction, and then removing the water Cheng Huan, get sets up lucky Kang Zuo key intermediate compound V, this invention uses the D, L - lactic acid methyl ester, by adding the catalyst induction to generate chiral center, greatly reducing the reaction of the raw material cost, high yield, high purity, easy controlled, is suitable for industrial production. (by machine translation)

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