A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
-
Page/Page column 2
(2012/08/28)
A Process for the Preparation of (R,S)-Nicotine
A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
-
Page/Page column 4
(2012/08/28)
Organocatalytic diimide reduction of enamides in water
Bridged flavinium organocatalysts have displayed efficacy in the diimide mediated reduction of enamides in aqueous conditions. This represents the first diimide reduction of an electron rich alkene and offers a clean alternative to the use of alkylating agents for N-alkylation.
Marsh, Barrie J.,Heath, Emma L.,Carbery, David R.
supporting information; experimental part
p. 280 - 282
(2011/02/23)
More Articles about upstream products of 117593-76-7