117626-82-1 Usage
Uses
Used in Pharmaceutical Development:
(1S)-1-(2-amino-6-oxo-1,6-dihydropyrimidin-5-yl)-1,4-anhydro-5-O-[(carboxymethyl)(hydroxy)phosphoryl]-D-ribitol is used as a key intermediate in the synthesis of pharmaceuticals for its potential to modulate biological activities. Its complex structure allows for the fine-tuning of drug properties, such as solubility, stability, and target specificity, which are crucial for the development of effective medications.
Used in Research and Development:
In the field of biological research, (1S)-1-(2-amino-6-oxo-1,6-dihydropyrimidin-5-yl)-1,4-anhydro-5-O-[(carboxymethyl)(hydroxy)phosphoryl]-D-ribitol serves as a valuable tool for studying the mechanisms of various cellular processes. Its unique functional groups can be exploited to probe interactions with biomolecules, such as enzymes, receptors, and nucleic acids, providing insights into the molecular basis of diseases and the discovery of novel therapeutic targets.
Used in Drug Delivery Systems:
(1S)-1-(2-amino-6-oxo-1,6-dihydropyrimidin-5-yl)-1,4-anhydro-5-O-[(carboxymethyl)(hydroxy)phosphoryl]-D-ribitol can be utilized in the design of drug delivery systems to improve the efficacy and safety of therapeutic agents. Its functional groups can be modified to facilitate targeted drug delivery, controlled release, and enhanced bioavailability, thereby optimizing the pharmacokinetic and pharmacodynamic properties of drugs.
Used in Chemical Synthesis:
In the chemical synthesis industry, (1S)-1-(2-amino-6-oxo-1,6-dihydropyrimidin-5-yl)-1,4-anhydro-5-O-[(carboxymethyl)(hydroxy)phosphoryl]-D-ribitol is employed as a versatile building block for the creation of a wide range of chemical compounds. Its diverse functional groups enable it to participate in various chemical reactions, making it suitable for the synthesis of complex organic molecules with specific properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 117626-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,6,2 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 117626-82:
(8*1)+(7*1)+(6*7)+(5*6)+(4*2)+(3*6)+(2*8)+(1*2)=131
131 % 10 = 1
So 117626-82-1 is a valid CAS Registry Number.
117626-82-1Relevant articles and documents
Synthesis and Antiviral Activity of Phosphonoacetic and Phosphonoformic Acid Esters of 5-Bromo-2'-deoxyuridine and Related Pyrimidine Nucleosides and Acyclonucleosides
Lambert, Robert W.,Martin, Joseph A.,Thomas, Gareth J.,Duncan, Ian B.,Hall, Michael J.,Heimer, Edgar P.
, p. 367 - 374 (2007/10/02)
Phosphonoacetic acid (PAA, 1) was coupled with various acyclonucleosides, 2'-deoxyuridines, cytidines, and arabinosyluracils, with 2,4,6-triisopropylbenzenesulfonyl chloride (TPS) or dicyclohexylcarbodiimide (DCCI) as condensing agents, to give a range of phosphonate esters.The carboxylic ester linkage of PAA to the 5'-position of 5-bromo-2'-deoxyuridine (BUdR, 3) was achieved via the mixed anhydride formed from (diethylphosphono)acetic acid and trifluoroacetic anhydride.Phosphonoformic acid (PFA, 2) was coupled with BUdR by using the DCCI method to give the phosphonate ester (59).Of these compounds only phosphonate esters in the 2'-deoxyuridine series showed significant activity against herpes simplex virus types 1 and 2.The BUdR-PAA derivative (7) and the BUdR-PFA derivative (59) were highly active, especially the latter, which was more active than the parent nucleoside BUdR (3) against the type 2 virus.The active compounds may exert their effects by extracellular or intracellular hydrolysis to the corresponding antiviral agents, but an intrinsic component of antiviral activity may also be involved.
