117856-61-8

Basic information

• Product Name: 2,5-Dimethoxypyrazine
• Synonyms: 2,5-Dimethoxypyrazine
• CAS NO: 117856-61-8
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.14
• Mol File: 117856-61-8.mol

Chemical Properties

• Melting Point: 108 °C
• Boiling Point: 186.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.131±0.06 g/cm3(Predicted)
• PKA: 0.14±0.10(Predicted)
• CAS DataBase Reference: 2,5-Dimethoxypyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethoxypyrazine(117856-61-8)
• EPA Substance Registry System: 2,5-Dimethoxypyrazine(117856-61-8)

Safety Data

• Hazardous Substances Data: 117856-61-8(Hazardous Substances Data)

Usage

Chemical class

Pyrazines

Physical state

Colorless liquid

Odor

Powerful, reminiscent of green peppers

Common uses

Flavoring agent in food and beverages

Natural occurrence

Found in various fruits, vegetables, wine, and coffee

Aroma characteristics

Earthy, green, and nutty

Functional use

Adds complexity and depth to the flavor profile of products

Potential applications

Insect attractant in pest control and agriculture

Upstream product

• 117856-49-2 2,5-dimethoxy-3,6-dihydropyrazine 
• 104124-05-2 (1Z)-4-(dimethyl-t-butylsilyloxy)-2-trimethylsilyl-1-(p-tolylsulphonyl)but-1-ene 

Relevant articles and documents

Synthesis of tert-Leucine and Related Amino Acids

The 2,5-dialkoxypyrazines 3a and b were prepared in three steps from methyl glycinate hydrochloride (1) in an overall yield of 18 and 63 percent.Upon the addition of lithium organyls to 3b and subsequent acid hydrolysis the ethyl glycinates rac-7 were obtained.Key Words: tert-Leucine / Amino acids / Glycine cation equivalents / Bislactim ether method

Radical Cations and Anions of Pyrazines: An Electron Paramagnetic Resonance Study

Dilute solutions of a series of pyrazines (1-13) in CFCl3 at 77 K were exposed to 60Co γ-rays, generating the corresponding radical cations which were identified by their EPR spectra.Two distinct types of spectra were observed.Those obtained from mono- and di-methyl derivatives showed large hyperfine coupling to the 14N nuclei similar to that of the parent pyrazine cation and are assigned to n(?)-radical cations.The other spectra observed for the tetramethyl, OCH3, SCH3, and RN2 derivatives are assigned to ?-radical cations.These findings confirm that the SOMO has switched from n(?) to ? between the dimethyl derivatives 4,6 and 8 and the tetramethyl compound 9, respectively.The NR2-substituted radical cations 12 and 13 were also observed in fluid solution.The corresponding radical anions 1-13, studied in solid solution, show major hyperfine coupling to the two ring 14N nuclei.Studies in fluid solution indicate that strong electron donor substituents (OCH3, SCH3, NR2) convert the S-type ?-SOMO of the pyrazine radical anion to a ?-SOMO with the predominant A-type character.

Synthetic Studies on Bicyclomycin and its Analogues. Part 1. Synthesis of Substituted 2-Oxa-8,10-diazabicyclodecanes

Methods have been developed for formation of the eight-membered oxygen-containing ring system (2) present in the antibiotic bicyclomycin.The procedure starts with N,N'-disubstituted piperazine-2,5-diones or the corresponding mono imino ethers.A new method is based on the oxidation of the mono imino ethers using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as oxidant: the bis imino ethers gave pyrazines under these conditions, whilst the parent piperazinedione proved to be unreactive.