- Synthetic method of homosalate
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The invention provides a method for synthesizing homosalate through an ester exchange reaction of methyl salicylate or ethyl salicylate and 3,3,5-trimethylcyclohexanol under the catalysis of an alkali. The method has the advantages of simple operation, high conversion rate, economy, environmental protection, and suitableness for industrial production.
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Paragraph 0023; 0024
(2016/11/21)
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- Method to reduce substantivity of cloth staining caused by sunscreens
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Suggested is a cosmetic and/or pharmaceutical preparation, especially dermatological preparation and its used for the protection of the human skin and human hair against the harmful effects of ultraviolet solar radiation comprising the water soluble UVA absorbing substance disodium phenyl dibenzimidazole tetrasulfonate, wherein the preparation is free from the UVA filters selected from the group consisting of 2,4-bis[{(4-(2-ethylhexyloxy)-2-hydroxy}phenyl]--6-(4-methoxyphenyl)-1,3,5-triazine, (Tinosorb?S), hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate (Uvinul? A Plus), 2-hydroxy-4-methoxybenzo-phenone (Benzophenone-3, Oxybenzone, Neo Heliopan? BB), Tris-Biphenyl Triazine (Tinosorb? A2B) or mixtures thereof.
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- PROCESS FOR TREATING SOL-GEL CAPSULES
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The present invention relates to a process for treating sol-gel capsules comprising a cosmetic or pharmaceutical active material with an inorganic material, as well as sol-gel capsules produced by a process according to the present invention and formulations comprising such sol-gel capsules.
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- COSMETIC COMPOSITIONS COMPRISING AN ESTER DERIVED FROM 4-CARBOXY-2-PYRROLIDINONE AND A MEROCYANIN SCREENING AGENT; USE OF SAID DERIVATIVE AS A SOLVENT FOR A MEROCYANIN SCREENING AGENT
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The present invention relates to a composition comprising, in a cosmetically acceptable medium, at least one ester derived from 4-carboxy-2-pyrrolidinone, of formula (I) below: in which: R1 denotes a linear or branched C1-C20 alkyl radical,R2 denotes a linear or branched C1-C20 alkyl radical that may contain a C5-C6 ring, the phenyl radical, the benzyl radical or the phenethyl radical,and at least one merocyanin-type UV screening agent. The present invention also relates to the use of at least one ester derived from 4-carboxy-2-pyrrolidinone, of formula (I), as defined above, in a composition comprising, in a cosmetically acceptable medium, at least one merocyanin-type UV screening agent, as a solvent for said merocyanin screening agent, in and/or as an agent for improving the solubility of said merocyanin screening agent in said composition or with the aim of improving the sun protection factor.
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- COSMETIC COMPOSITIONS COMPRISING AN ESTER DERIVED FROM 4-CARBOXY-2-PYRROLIDINONE AND A LIPOPHILIC SCREENING AGENT; USE OF SAID DERIVATIVE AS A SOLVENT FOR A BENZOPHENONE LIPOPHILIC SCREENING AGENT
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The present invention relates to a composition comprising, in a cosmetically acceptable medium, at least one ester derived from 4-carboxy-2-pyrrolidinone, of formula (I) below: in which: R1 denotes a linear or branched C1-C20 alkyl radical,R2 denotes a linear or branched C1-C20 alkyl radical that may contain a C5-C6 ring, the phenyl radical, the benzyl radical or the phenethyl radical,and at least one benzophenone-type lipophilic UV screening agent. The present invention also relates to the use of at least one ester derived from 4-carboxy-2-pyrrolidinone, of formula (I), as defined above, in a composition comprising, in a cosmetically acceptable medium, at least one benzophenone-type lipophilic UV screening agent, as a solvent for said benzophenone screening agent, in and/or as an agent for improving the solubility of said benzophenone screening agent in said composition or with the aim of improving the sun protection factor.
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- COSMETIC TREATMENT METHOD USING A COMPOUND THAT CAN BE CONDENSED IN SITU AND A UV-RADIATION-FILTERING AGENT
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The present invention relates to a method for the cosmetic treatment of the skin, comprising the application, to the skin: of a compound or group of compounds A capable of condensing in situ and exhibiting at least one reactive functional group FA which is free after condensation; and of a screening agent C which screens out UV radiation, comprising a reactive functional group FC capable of forming a covalent bond or a physical (ionic, hydrogen) bond by reaction with the functional group FA.
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- FLUID OIL-IN-WATER SUNSCREEN EMULSIONS CONTAINING GEMINI SURFACTANTS AND A CROSSLINKED COPOLYMER OF METHACRYLIC ACID AND OF C1-C4 ALKYL ACRYLATE
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The present invention relates to a photoprotective composition containing, in a cosmetically acceptable medium, a) as liquid phase, an oil-in-water emulsion, emulsified with at least one dimeric surfactant comprising two surfactant units, which may be identical or different, each being constituted of a hydrophilic head and a hydrophobic tail and connected to one another, via the hydrophilic heads, by means of a spacer group, b) at least one organic UV screen and/or at least one mineral UV screen, and c) at least one crosslinked copolymer of methacrylic acid and of Ci-C4 alkyl acrylate.
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- ANHYDROUS FLUID FILTERING COMPOSITION COMPRISING AN OILY PHASE, A PARTICULAR TRIAZINE FILTER AND AN OIL THICKENING OR GELLING RHEOLOGICAL AGENT
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The present invention relates to an anhydrous fluid composition comprising, in a cosmetically acceptable medium: a) at least one oily phase and b) at least one particular triazine UV filter of formula (I) and c) at least one rheological agent for thickening or gelling the oily phase. The present invention also relates to the use of said composition for the manufacture of products for the cosmetic treatment of the skin, nails, hair, eyelashes, eyebrows and/or scalp, notably care products, sun protection products, make-up products.
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- Photoprotective compositions comprising photosensitive 1,3,5-triazine compounds, dibenzoylmethane compounds and siliceous s-triazines substituted with two aminobenzoate or aminobenzamide groups
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UV-photoprotective, topically applicable cosmetic/dermatological compositions contain: (a) at least one dibenzoylmethane compound,(b) at least one 1,3,5-triazine compound that is photosensitive in the presence of a dibenzoylmethane compound, and(c) at least one siliceous s-triazine compound substituted with two aminobenzoate or aminobenzamide groups, or a tautomeric form thereof, the 1,3,5-triazine compounds being improvedly photostable in such compositions.
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- Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor
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Cosmetic/sunscreen compositions contain a combination of at least one dibenzoylmethane sunscreen compound and a photostabilizing amount of at least one dithiolane compound of formula (I) below:
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- SUN PROTECTION KIT
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The present invention relates to a kit for protecting keratin materials against UV radiation in the range above 280 nm, encompassing the UVA and the UVB rays, comprising at least two different, separately packaged compositions, said kit comprising at least one compound (X), at least one compound (Y), and at least one hydrophobic screening system comprising (i) at least one hydrophobic organic sunscreen agent (A) capable of absorbing the UV radiation of 320 to 400 nm and at least one hydrophobic organic sunscreen agent (B) capable of absorbing the UV radiation of 280 to 320 nm, and optionally an inorganic sunscreen agent (D); (ii) at least one hydrophobic organic sunscreen agent (C) capable of absorbing simultaneously the UV radiation of 280 to 320 nm and 320 to 400 nm, and optionally an inorganic sunscreen agent (D); or (iii) at least one hydrophobic organic sunscreen agent (A) capable of absorbing the UV radiation of 320 to 400 nm and either at least one hydrophobic organic sunscreen agent (C) capable of absorbing simultaneously the UV radiation of 280 to 320 nm and 320 to 400 nm, or at least one inorganic sunscreen agent (D); at least one of said compounds (X) and (Y) being a silicone compound.
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- UV LIGHT-PROTECTIVE AGENT BASED ON MIXED INORGANIC-ORGANIC SYSTEMS
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The present invention relates to photoprotective preparations, in particular in the field of cosmetics, based on inorganic-organic mixed systems. The present invention relates in particular to photoprotective preparations comprising nanoparticles of at least one metal derivative, at least one photoprotective compound chemically bonded to these metal derivative nanoparticles, and at least one further organic UV photoprotective agent which is different from the photoprotective compound bonded to the metal derivative nanoparticles.
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- Cosmetic compositions comprising photostabilized dibenzoylmethane compounds and 2-pyrrolidinone-4- carboxy esters
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Photostable cosmetic compositions contain, formulated into a cosmetically acceptable vehicle, at least one UV-screening system that includes: (a) at least one dibenzoylmethane compound, and(b) at least one 2-pyrrolidinone-4-carboxy ester compound having the following formula (I): in which: R1 is a linear or branched C1-C20 alkyl radical, andR2 is a linear or branched C1-C20 alkyl radical which optionally includes a C5-C6 ring member, the phenyl radical, the benzyl radical or the phenethyl radical.
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- Cosmetic compositions comprising 4-carboxy-2-pyrrolidinone esters and triazine lipophilic UV-screening agents
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UV-screening compositions, formulated into a cosmetically acceptable medium, contain at least one ester solvent derived from 4-carboxy-2-pyrrolidinone, of formula (I) below: in which: R1 is a linear or branched C1-C20 alkyl radical,R2 is a linear or branched C1-C20 alkyl radical that may contain a C5-C6 ring member, the phenyl radical, the benzyl radical or the phenethyl radical, and at least one triazine-type lipophilic UV-screening agent.
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- OIL-IN-WATER EMULSION
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The present invention relates to a composition in the form of an emulsion of the oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and which are dispersed in an aqueous phase, wherein it has a pH ranging from 3 to 5.5 and in that it contains at least one lipophilic surface-active agent with an HLB ranging from 2 to 5, at least one hydrophilic surface-active agent with an HLB ranging from 8 to 12 and at least one amphiphilic compound of ionic nature at a pH ranging from 3 to 5.5.
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- COSMETIC AND/OR DERMATOLOGICAL COMPOSITION BASED ON N,N'-DIARYLMETHYLENEETHYLENEDIAMINEDIACETIC ACID ESTER(S)
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The present invention relates to a cosmetic and/or dermatological composition comprising, in a physiologically acceptable medium containing at least one oil: (a) at least one compound of general formula (Ia): and (b) an efficient amount of at least one solvent chosen from: (i) isononyl isononanoate;(ii) dimethyl isosorbide;(iii) the amino acid esters of formula (II): [in-line-formulae]R′1(CO)N(R′2)CH(R′3)(CH2)n(CO)OR′4??(II)[/in-line-formulae](iv) and a mixture thereof.
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- OLEO-ALCOHOLIC ANHYDROUS FLUID SCREENING COMPOSITION COMPRISING A LIPOPHILIC POLYAMIDE POLYCONDENSATE
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The present invention relates to an anhydrous fluid composition comprising, in a cosmetically acceptable medium: a) at least one hydrocarbon oil andb) at least one lipophilic organic UV screening agent andc) at least one linear C1-C3 monoalcohol, in particular ethanol, andd) at least one lipophilic polyamide polycondensate. The present invention also relates to the use of the said composition in the manufacture of products for the cosmetic treatment of the skin, nails, hair, eyelashes, eyebrows and/or scalp, in particular care products, sun protection products, makeup products or scenting products.
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- Aqueous fluid photoprotective compositions comprising tertiary-amide-terminated polyamide polymers
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Topically applicable, fluid anti-sun/sunscreen compositions useful for protecting the skin and/or the hair against the damaging effects of ultraviolet radiation, contain: (a) at least one photoprotective system for screening out UV radiation; and(b) at least one tertiary-amide-terminated polyamide (ATPA) polymer, formulated into a topically applicable, cosmetically acceptable aqueous support therefor; the subject anti-sun/sunscreen compositions are especially provided as sprays, notably for the purpose of increasing the sun protection factor (SPF) and/or of reducing or even eliminating the fluffing effect thereof.
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- COMPOSITION CONTAINING A PHENANTHRENOL
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Novel uses of phenanthrenol compounds for improving the appearance and/or texture of the skin.
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- Sun protection compositions comprising semi-crystalline polymers and hollow latex particles
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Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30° C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.
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- Photostable cosmetic compositions comprising dibenzoylmethane/pyrrolidinone compounds
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Photostable UV-photoprotecting cosmetic sunscreen compositions contain (a) an effective UV-photoprotecting amount of at least one dibenzoylmethane compound sunscreen, (b) an effective radiation-photostablizing amount of at least one pyrrolidinone compound having the formula (I) below: and, advantageously, at least one liquid fatty phase and at least one lipophilic active sunscreen agent of low solubility, formulated into (c) a cosmetically acceptable support therefor.
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- Photoprotective cosmetic compositions comprising photostabilized dibenzoylmethane compounds and siloxane-containing arylalkyl benzoate amide compounds
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Photostable, topically applicable cosmetic/dermatological compositions contain at least one dibenzoylmethane sunscreen compound and at least one photostabilizing siloxane-containing arylalkyl amide compound of formula (I) below:
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- Flavonoid derivative
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The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative or extract.
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- Photoprotective compositions comprising sulfonic/hydrophobic amphiphilic polymers
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Photoprotective cosmetic/dermatological compositions well suited for the UV-photoprotection of human skin and/or hair, comprise (a) at least one organic UV-screening agent and (b) an SPF-improving amount of at least one amphiphilic polymerizate of at least one ethylenically unsaturated monomer which comprises a sulfonic group, whether in the free acid or in partially or totally neutralized state, and which amphiphilic polymerizate also comprises at least one hydrophobic moiety.
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- Use of aryl oximes for the prophylaxis and/or treatment of erythema formation and/or inflammatory reaction of the skin
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The present invention relates to the use of at least one aryl oxime of Formula (I). wherein: Y, Z represent independently from each other H, C1-18 alkyl, C2-18 alkenyl, C2-18 carboxy alkyl, C3-18 carboxy alkenyl or C2-18 alkanoyl; R represents C1-18 alkyl, C2-18 alkenyl, C3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R1, R2, R3 and R4 represent independently from each other H, C1-12 alkyl, C2-12 alkenyl, C1-12 alkoxy, C3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl, for the prophylaxis and/or treatment of erythema formation and/or inflammation responses of the skin.
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- Topical composition containing at least one aryl oxime, and method for the preparation thereof
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The present invention relates to a topical composition, comprising (c) at least one aryl oxime of the Formula (I) and (d) at least one emulsifier, wherein: Y, Z represent independently from each other H, C1-18 alkyl, C2-18 alkenyl, C2-18 carboxy alkyl, C3-18 carboxy alkenyl or C2-18 alkanoyl; R represents C1-18 alkyl, C2-18 alkenyl, C3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R1, R2, R3 and R4 represent independently from each other H, C1-12 alkyl, C2-12 alkenyl, C1-12 alkoxy, C3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl, wherein the component (b) is selected from the group consisting of an ester, the carboxylic acid residue of which is derived from C5-C16 acids and the hydroxyl residue of which is derived from monomers, dimers or trimers of lactic acid or one of its salts or a polyglycerin of 2 to 10 molecules of glycerin whereby 1 to 3 moles of carboxylic acid are present per mole of polyglycerin. Furthermore, the present invention relates to a process for the preparation of said topical composition as well as the use of said topical composition.
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- Composition containing at least one aryl oxime and at least one active substance for treating acne and the use thereof
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The present invention relates to a composition, comprising (a) at least one aryl oxime of Formula (I) and (b) at least one active agent for the treatment of acne ?wherein: Y, Z represent independently from each other H, C1-18 alkyl, C2-18 alkenyl, C2-18 carboxy alkyl, C3-18 carboxy alkenyl or C2-18 alkanoyl; R represents C1-18 alkyl, C2-18 alkenyl, C3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R1, R2, R3 and R4 represent independently from each other H, C1-12 alkyl, C2-12 alkenyl, C1-12 alkoxy, C3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl. Moreover, the present invention relates to the use of this composition as well as the use of the aforementioned aryl oxime of Formula (I).
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- Use of ectoin or ectoin derivatives for the prophylaxis and/or treatment of uv-induced immunosuppression
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The present invention relates to the use of at least one compound selected from the group comprising compounds of formulas 1a and 1b physiologically acceptable salts thereof and stereoisomeric forms thereof, in which R1 denotes H oder alkyl, R2 denotes H, COOH, COO-alkyl or CO—NH—R5, R3 and R4 each independently denote H or OH, n is 1, 2 or 3, R5 denotes H, alkyl, an amino acid group, a dipeptide residue or a tripeptide residue, and alkyl denotes an alkyl group containing from 1 to 4 carbons, for the prophylaxis and/or treatment of immunosuppression. These compounds are used in the present invention in the form of a topical composition.
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- Use of ectoin or ectoin derivatives for stabilizing p53
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This invention relates to the use of at least one compound, selected from a compound of the formula 1a, 1b, 1a physiologically compatible salt of it and a stereoisomeric form of it, whereby the following signify R1 H or alkyl, R2 H, COOH, COO-alkyl or CO—NH—R5, R3 and R4 each mutually independent H or OH, n 1, 2 or 3, R5 H, alkyl, an amino acid residue, a dipeptide residue or tripeptide residue, and alkyl an alkyl residue with 1 to 4 carbon atoms, for the stabilisation of p53. According to the invention, these compounds are normally used in the form of a topical composition.
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- Method for producing luteolin and luteolin derivatives
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Disclosed is a method for producing compounds of formula (I), wherein R1represents H or (CH2)mOH, R2represents H or (CH2)nOH, R3represents H or (CH2)pOH and m, n and p represent 2-8 independently from one another. Said compounds are particularly suitable for use as food supplements. They are highly suitable for use in cosmetic formulations as UV filters, for instance.
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- Formulation for protection against oxidative stress containing benzofuranone derivatives
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The invention relates to a cosmetic or pharmaceutical formulation comprising at least one compound of formula (I). The cosmetics or pharmaceutical products are particularly suitable for the care of the skin in protecting against oxidative stress and ageing phenomena.
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- Preparation containing quinoxaline derivatives
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The invention relates to the use of quinoxaline derivatives as photostable UV filters in cosmetic and pharmaceutical preparations for protecting the human epidermis or human hair against UV radiation, especially in the 280-400 nm range.
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- Galenic formulation
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Cosmetic or dermatological formulations which comprise one or more active ingredients selected from phylloquinone, 2-hydroxy-5-methyllaurophenone oxime, vitamin A and its derivatives, vitamin E and its derivatives, vitamin H, allantoin, bisabolol, nicotinic acid derivatives and caffeine and in addition (a) one or more antioxidants and/or (b) one or more UV filters, are distinguished, in particular, by the fact that the active ingredients present in the formulation according to the invention are stabilised.
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- Galenical formulation
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The invention relates to compounds of the formula I 1where R1, R2, R3, R4 and R5 have the meanings given in claim 1. The compound is suitable in particular for use in skin care compositions. They protect, firstly, against harmful oxidation reactions and, secondly, also act as UV filters.
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- Transparent cosmetic composition that reflects infrared radiation and its use for protecting the human epidermis against infrared radiation
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Transparent cosmetic composition that reflects infrared radiation and its use for protecting the human epidermis against infrared radiation. The invention relates to a transparent cosmetic composition comprising, by way of an agent that reflects infrared radiation for protecting the human epidermis, a substance which is dispersible in the cosmetic medium used, possessing a reflectance (R) of infrared radiation equal to at least 45%, and of which a 2% strength dispersion in vaseline possesses an optical transmission in the visible of at least 85%, chosen from a diatom of particle size less than 100 microns, hollow glass microspheres of size less than 100 microns, a bismuth oxychloride of particle size less than 75 microns and zirconium powder covered ceramic microparticles of particle size less than 8 microns. This cosmetic composition can also contain 0.5 to 20% by weight of UV-A, UV-B or broad-band screening agents.
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- Cosmetic screening composition containing a UV screen in combination with a polymer obtained by block polymerization in emulsion and its use for the protection of the human epidermis against ultraviolet radiations
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Cosmetic screening composition containing a UV screen in combination with a polymer obtained by block polymerization in emulsion and its use for the protection of the human epidermis against ultraviolet radiations.
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