Stereoselective synthesis of spirooxindoles by palladium-catalyzed decarboxylative cyclization of γ-methylidene-β-valerolactones with isatins
Image Presented A new synthetic method of spirooxindole derivatives has been developed by way of a palladium-catalyzed decarboxylative cyclization of γ-methylidene-β-valerolactones with isatins. By employing a newly prepared phosphoramidite ligand, the re