- A 2, 4, 6- three fluorine animal pens method for the preparation of amine compounds
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The invention relates to a preparation method of a 2,4,6-trifluoro-benzylamine compound. The preparation method comprises the following steps: taking 1,3,5-trifluoro-benzene as a raw material, and preparing 2,4,6-trifluoro-benzylamine through lithiation, formylation, reduction, halogenation and replacement reaction. The reaction condition is mild, the operability is high, the atom economy is high, the technology is simple and easy to realize industrialization, and the product is high in purity and stable in quality, so that the compound accords with the using requirement of being as an intermediate.
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- Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency
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Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calculations. Optimization of the 4-R substituent in 1 led to ethyl and isopropyl analogs 1e and 1f with 1-7 nM potency towards both the wild-type virus and a Tyr181C variant.
- Bollini, Mariela,Gallardo-Macias, Ricardo,Spasov, Krasimir A.,Tirado-Rives, Julian,Anderson, Karen S.,Jorgensen, William L.
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p. 1110 - 1113
(2013/03/14)
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- Method for control of soil-borne insects
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A method for controlling soil-borne insects such as southern corn rootworm is disclosed and exemplified in which the pyrethroid 2,4,6-trifluorophenylmethyl 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate is applied to the soil
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