118462-63-8Relevant articles and documents
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF CONJUGATES OF PREDNISOLONE AND NON-STEROIDAL ANTI-INFLAMMATORY AGENTS
McLean, Hugh M.,Lee, Henry J.
, p. 421 - 440 (1989)
Esters of prednisolone with ibuprofen and indomethacin were prepared by coupling the 21-hydroxy moiety of the glucocorticoid to the carboxylic group of the non-steroidal anti-inflammatory agents.The local and systemic anti-inflammatory activities of the c
Binding of conjugates of prednisolone and non-steroidal anti-inflammatory drugs to glucocorticoid receptors and their acute pharmacological activities in rats
McLean, Hugh M.,Lee, Henry J.
, p. 238 - 247 (2007/10/03)
Esters of prednisolone with ibuprofen (ibupred) and indomethacin (indopred) were evaluated for their binding affinity to a rat hepatic glucocorticoid receptor preparation and their acute pharmacological effects in male Sprague-Dawley rats. Both conjugates