118469-11-7

Basic information

• Product Name: 1H-Benzimidazole-2-methanol,1-(2-propynyl)-(9CI)
• Synonyms: 1H-Benzimidazole-2-methanol,1-(2-propynyl)-(9CI)
• CAS NO: 118469-11-7
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.2099
• Product Categories: BENZIMIDAZOLE
• Mol File: 118469-11-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Benzimidazole-2-methanol,1-(2-propynyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-2-methanol,1-(2-propynyl)-(9CI)(118469-11-7)
• EPA Substance Registry System: 1H-Benzimidazole-2-methanol,1-(2-propynyl)-(9CI)(118469-11-7)

Safety Data

• Hazardous Substances Data: 118469-11-7(Hazardous Substances Data)

Upstream product

• 291536-12-4 N¹-(prop-2-yn-1-yl)benzene-1,2-diamine 
• 64266-27-9 3-(2-Hydroxymethyl-benzoimidazol-1-yl)-propionitrile 
• 4856-97-7 2-(Hydroxymethyl)benzimidazole 
• 106-96-7 propargyl bromide 

Downstream Products

• 156576-12-4 3-methyl-1H-benzo[4,5]imidazo[2,1-c][1,4]oxazine 

Relevant articles and documents

Sustainable Synthesis of 2-Hydroxymethylbenzimidazoles using D-Fructose as a C2 Synthon

D-fructose, a biomass-derived carbohydrate has been identified as an environmentally benign C2 synthon in the preparation of synthetically useful 2-hydroxymethylbenzimidazole derivatives by coupling with 1,2-phenylenediamines. Proof of concept was established by synthesizing 23 examples using BF3.OEt2 (20 mol%), TBHP (5.5 M, decane) (1.0 equiv.) in CH3CN at 90 °C for 1 h. The pivotal features of this method include metal-free conditions, short time, good functional group tolerance, gram scale feasibility and the synthesis of benzimidazole fused 1,4-oxazine. Control studies with conventional C2 synthons did not produce the desired product, thus suggesting a new reaction pathway from D-fructose.

Investigations of unsaturated azoles. 13. Synthesis and some reactions of 1-alkylbenzimidazoles

Methods of direct alkylation of benzimidazoles by haloalkanes in homogeneous medium and under phase transfer catalysis conditions together with cyanoethylation by acrylonitrile are reported. The dealkylation of quaternary benzimidazole salts was also studied. 1997 Plenum Publishing Corporation.

LE 2-HYDROXYMETHYLBENZIMIDAZOLE PRECURSEUR DE SYNTHESE DE NOUVEAUX SYSTEMES HETEROCYCLIQUES

The easy synthesis of 2-hydroxymethylbenzimidazole, leads us to use this compound in the preparation of new heterocyclic systems.

6-beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof

Antibacterial penicillins of the formula STR1 or a pharmaceutically acceptable salt thereof wherein R1 is a heterocyclic group and R is hydrogen, the residue of certian carboxy protecting groups or the residue of an ester group readily hydrolyzable in vivo having activity against resistant organisms.