New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation
A series of substituted 6-nitrophenylpropanamide derivatives (1-20) were synthesized using either the TDAE strategy or classical organic reactions. All these compounds were characterized by fusion point, 1H NMR, 13C NMR, elemental an
Since, Marc,Freret, Thomas,Nee, Gerald,Terme, Thierry,Vanelle, Patrice,Boulouard, Michel
p. 728 - 734
(2013/10/22)
Original TDAE strategy using α-halocarbonyl derivatives
We report herein the selective C-C bond formation by the reaction of nitrobenzyl carbanions, formed via the TDAE strategy, with α-haloesters and α-haloamides. This reaction, extended in benzodioxole and dimethoxybenzene series provides new potentially CNS
Since, Marc,Terme, Thierry,Vanelle, Patrice
experimental part
p. 6128 - 6134
(2011/03/19)
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