- Compounds useful as reversible inhibitors of cysteine proteases
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Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.
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- Compounds useful as reversible inhibitors of cysteine proteases
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Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
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- Novel compounds useful as reversible inhibitors of cysteine proteases
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Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The co
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- Pyrimidine-5-carbonitriles from Methyl N-(Aminocarbonyl)- or N-(Aminothiocarbonyl)-imidates
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A number of substituted pyrimidine-5-carbonitriles and ethyl pyrimidine-5-carboxylates are prepared by reaction of methyl N-(aminocarbonyl)- or N-(aminothiocarbonyl)imidates with malononitrile, methyl cyanoacetate, or diethyl malonate.
- Krechl, Jiri,Perez, Miguel A.,Cuadrado, Francisco J.,Soto, Jose L.
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p. 122 - 124
(2007/10/02)
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