- The first total synthesis of (-)-sinulariol-B and three other cembranoids
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The first total synthesis of (-)-sinulariol-B, a marine cembrandiol, was achieved from geraniol. Three other cembranoids were also synthesized from (- )-sinulariol-B.
- Lan, Jiong,Li, Jing,Liu, Zuosheng,Li, Yulin,Chan, Albert S. C.
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p. 1877 - 1885
(2007/10/03)
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- Marine Terpenes and Terpenoids. VI. Isolation of Several Plausible Precursors of Marine Cembranolides, from the Soft Coral, Sinularia mayi
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Six new cembranoid diterpenes, sinulariols C and D (1 and 2a), sinularial A (3), sinularic acid A (4), and sinularones A and B (5 and 6) were isolated from the lipid extract of the soft coral Sinularia mayi, together with four known compounds.The structures of the new compounds were elucidated by means of spectroscopic analyses, Horeau determination, and chemical conversion.Sinulariol C (1) was found to be an C-14 isomer of "13-hydroxyneocembrene" (8a) and gave sinularone A (5) on oxidation.Sinularial A (3) is the first example of a cembranoid aldehyde isolated from marine sources.Compounds 1 to 4 are plausible precursors to the cembranoid lactones found in various soft corals.Keywords - soft coral; Sinularia mayi; cembranoid; sinulariol C; sinulariol D; sinularial A; sinularic acid A; sinularone A; sinularone B
- Kobayashi, Masaru,Hamaguchi, Takuya
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p. 3780 - 3786
(2007/10/02)
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