Discovery of highly potent and selective type I B-Raf kinase inhibitors
A series of pyrazolo[1,5-α]pyrimidine analogs has been prepared and found to be potent and selective B-Raf inhibitors. Molecular modeling suggests they bind to the active conformation of the enzyme.
Wang, Xiaolun,Berger, Dan M.,Salaski, Edward J.,Torres, Nancy,Hu, Yongbo,Levin, Jeremy I.,Powell, Dennis,Wojciechowicz, Donald,Collins, Karen,Frommer, Eileen
scheme or table
p. 6571 - 6574
(2010/06/12)
BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF
Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.
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Page/Page column 61-62
(2009/10/21)
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