The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus
β-2′-C-Methyl purines (1, 2) are known inhibitors of hepatitis C virus (HCV). We herein report the synthesis, biological and enzymatic evaluation of their 5′-phosphoramidate ProTides. Described herein are seven l-alanine phosphoramidate derivatives with v
McGuigan, Christopher,Perrone, Plinio,Madela, Karolina,Neyts, Johan
scheme or table
p. 4316 - 4320
(2010/06/19)
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