cas 1186663-45-5, Methyl 3-Bromo-1-methylindole-6-carboxylate | Articles data ｜lookchem

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1186663-45-5

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Sodium channel blockers (by machine translation)
The invention belongs to the field of medicines, and particularly relates to a compound shown as a formula (I). A pharmaceutical composition comprising the compound, a pharmaceutically acceptable salt, a solvate or an isomer thereof, a pharmaceutically ac
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Paragraph 0278-0281

(2020/11/05)

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain
3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Nav1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse formalin assay and also reduced complete Freund's adjuvant (CFA)-induced thermal hyper
Luo, Guanglin,Chen, Ling,Easton, Amy,Newton, Amy,Bourin, Clotilde,Shields, Eric,Mosure, Kathy,Soars, Matthew G.,Knox, Ronald J.,Matchett, Michele,Pieschl, Rick L.,Post-Munson, Debra J.,Wang, Shuya,Herrington, James,Graef, John,Newberry, Kimberly,Sivarao, Digavalli V.,Senapati, Arun,Bristow, Linda J.,Meanwell, Nicholas A.,Thompson, Lorin A.,Dzierba, Carolyn
p. 831 - 856
(2019/01/21)

ACYL SULFONAMIDE NaV1.7 INHIBITORS
The present disclosure relates to compounds of formula I which inhibit NaV1.7, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
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Page/Page column 20; 21

(2017/11/15)

More Articles about upstream products of 1186663-45-5

Chemical Properties

Boiling Point: 373.0±22.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C
PSA: 31.23000
LogP: 2.72740

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