Synthesis and anti-HIV-1 evaluation of new Sonogashira-modified emivirine (MKC-442) analogues
The MKC-442 analogue 6-(3,5-dimethylbenzyl)-5-ethyluracil substituted with a (propargyloxo)-methyl group at N(1) has previously been found highly active against HIV-1. The C≡C bond in the substituent at N(1) is here utilized in a series of chemical reacti
Danel, Krzysztof,Jorgensen, Per T.,Pedersen, Erik B.,La Colla, Paolo,Collu, Gabriella,Loddo, Roberta
experimental part
p. 1385 - 1403
(2009/10/16)
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