- Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors
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Abstract Herein we have reported design, synthesis and in vitro biological evaluation of a library of bicyclic lactams that led to the discovery of compounds 6 and 7 as a novel class of α-glucosidase inhibitors. They inhibited α-glucosidase (yeast origin)
- Hati, Santanu,Madurkar, Sanjay M.,Bathula, Chandramohan,Thulluri, Chiranjeevi,Agarwal, Rahul,Siddiqui, Faiza Amber,Dangi, Poonam,Adepally, Uma,Singh, Ashutosh,Singh, Shailja,Sen, Subhabrata
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p. 188 - 196
(2015/06/22)
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- Efficient total synthesis of AI-77-B, a gastroprotective substance from Bacillus pumilus AI-77
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First total synthesis of AI-77-B (1), a gastroprotective substance from Bacillus pumilus AI-77, was achieved in a stereoselective and convergent manner. In this synthesis, the dihydroisocoumarin part 2 was constructed in one step through 1,2-addition of the benzylic anion 17b to Boc-L-leucinal 7b. The hydroxy amino acid 4 was elaborated from (R)-glutamic acid in a highly stereoselective manner. Condensation of 2·HCl and 4, intramolecular Pinner reaction, followed by mild hydrolysis afforded AI-77-B (1).
- Hamada,Hara,Kawai,Kohno,Shioiri
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p. 8635 - 8652
(2007/10/02)
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