Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity
New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H 4-C6H4CH2) showed a cytotoxicity with IC50 ≈ 10 μM.
NOVEL DIHYDROXYPYRROLIDINE DERIVATIVES AS ANTI-CANCER AGENTS
The present invention provides new dihydroxypyrrolidine derivatives for use as medicaments. The compounds are useful in the treatment in cancer, in particular non-solid neoplasms.
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(2009/10/22)
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