Selective chemical oxidation of risperidone: A straightforward and cost-effective synthesis of paliperidone
A very short and cost-effective synthesis of the commercial drug paliperidone has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions. A very short and cost-effective synthesis of the commercial drug paliperidone (1) has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions. Copyright
NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE
The present invention relates to a novel process for the preparation of paliperidone and its intermediates and also relates to an improved process for the preparation of paliperidone compound of formula (I).
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Page/Page column 10; 18
(2010/04/03)
One-step process for preparing paliperidone and its oxalate salt
The present invention relates to a one-step process for the preparation of the antipsychotic agent Paliperidone by oxidation of Risperidone, and to Paliperidone oxalate or a hydrate, solvate or polymorph thereof.
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Page/Page column 6
(2010/07/06)
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