1190312-37-8

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester;6-Chloro-7-azaindole-4-carboxylic acid Methyl ester;methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate
• CAS NO: 1190312-37-8
• Molecular Formula: C₉H₇ClN₂O₂
• Molecular Weight: 210.61708
• Mol File: 1190312-37-8.mol

Chemical Properties

• Appearance: /
• Density: 1.453±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.78±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester(1190312-37-8)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, Methyl ester(1190312-37-8)

Safety Data

• Hazardous Substances Data: 1190312-37-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, methyl ester is used as a potential active pharmaceutical ingredient for the development of new drugs, targeting various diseases. Its unique structure and functional groups contribute to its potential therapeutic applications.
Used in Organic Synthesis:
1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, methyl ester serves as a building block in the synthesis of various organic compounds, facilitating the creation of new molecules with specific properties and functions.
Used in Medicinal Chemistry Research:
1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, 6-chloro-, methyl ester is used as a research tool in the study of biological systems, aiding in the understanding of disease mechanisms and the discovery of new therapeutic targets.

Upstream product

• 479553-01-0 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 
• 1201748-37-9 4-(methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine 7-oxide 
• 351439-07-1 methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate 

Downstream Products

• 1261476-04-3 6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 
• 1312812-82-0 tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxamido)methyl)cyclohexyl)methyl]carbamate 
• 1261744-93-7 methyl 6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylate 
• 1167056-92-9 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 

Relevant articles and documents

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good physical and in vitro ADME properties and good bioavailability. X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both 33 and 37 lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats.

NOVEL DERIVATIVES OF PYRROLOINDOLE WHICH ARE INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF

Pyrroloindoles of formula (I) are provided wherein Het is an aromatic or partially unsaturated, monocyclic or bicyclic heterocycle containing between 1 and 4 heteroatoms N, O or S, optionally substituted by R1 or R′1 which are the same or different; R is