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CAS

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1190363-45-1

(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one is a chemical compound characterized by its molecular formula C21H39NO2Si. It is a derivative of cyclohepta[b]pyridin-5-one, featuring a triisopropylsilyl group attached to the oxygen atom. This white solid is primarily utilized as a reagent in organic synthesis, with its unique structure and reactivity making it a valuable component in the development of new pharmaceuticals and agrochemicals. It also holds potential in medicinal chemistry and the creation of novel materials.

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  • (9R)-9-[(triisopropylsilyl)oxy]-6H,7H,8H,9H-cyclohepta[b]pyridin-5-one hydrochloride

    Cas No: 1190363-45-1

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  • 1190363-45-1 Structure

  • Basic information

    1. Product Name: (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one
    2. Synonyms: (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one
    3. CAS NO:1190363-45-1
    4. Molecular Formula:
    5. Molecular Weight: 333.546
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1190363-45-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one(1190363-45-1)
    11. EPA Substance Registry System: (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one(1190363-45-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1190363-45-1(Hazardous Substances Data)

1190363-45-1 Usage

Uses

Used in Pharmaceutical Development:
(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one is used as a reagent in the synthesis of new pharmaceuticals for its unique structural and reactive properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Development:
In the agrochemical industry, (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one is employed as a reagent in the creation of new agrochemicals, leveraging its distinctive structure to enhance crop protection and yield.
Used in Medicinal Chemistry Research:
(R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one is utilized as a research compound in medicinal chemistry, exploring its potential applications and interactions within biological systems to develop innovative therapeutic agents.
Used in Material Science:
In the field of material science, (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one is used as a component in the development of novel materials, capitalizing on its unique properties to create new substances with specialized applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1190363-45-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,0,3,6 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1190363-45:
(9*1)+(8*1)+(7*9)+(6*0)+(5*3)+(4*6)+(3*3)+(2*4)+(1*5)=141
141 % 10 = 1
So 1190363-45-1 is a valid CAS Registry Number.

1190363-45-1Downstream Products

1190363-45-1Relevant articles and documents

Efficient and scalable enantioselective synthesis of a CGRP antagonist

Leahy, David K.,Fan, Yu,Desai, Lopa V.,Chan, Collin,Zhu, Jason,Hanson, Ronald L.,Sugiyama, Masano,Rosner, Thorsten,Cuniere, Nicolas,Guo, Zhiwei,Hsiao, Yi,Luo, Guanglin,Chen, Ling,Gao, Qi

supporting information, p. 4938 - 4941,4 (2012/12/12)

An enantioselective synthesis of the CGRP antagonist BMS-846372, amenable to large scale preparation, is presented. This new synthesis showcases a chemo- and enantioselective reduction of a cyclohepta[b]pyridine-5,9-dione as well as a Pd-catalyzed alpha-arylation reaction to form the key carbon-carbon bond and set the absolute and relative stereochemistry.

CGRP Receptor Antagonists

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Page/Page column 31, (2009/10/21)

The disclosure generally relates to the novel compounds of formula I, including their salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).

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