1190932-38-7

Basic information

• Product Name: COH-29
• Synonyms: COH-29;N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide
• CAS NO: 1190932-38-7
• Molecular Formula: C22H16N2O5S
• Molecular Weight: 420.43784
• EINECS: -0
• Mol File: 1190932-38-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: COH-29(CAS DataBase Reference)
• NIST Chemistry Reference: COH-29(1190932-38-7)
• EPA Substance Registry System: COH-29(1190932-38-7)

Safety Data

• Hazardous Substances Data: 1190932-38-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
COH-29 is used as an anti-cancer agent for its ability to specifically target and inhibit the activity of human ribonucleotide reductase (RRM2), thereby disrupting the replication process of cancer cells and potentially leading to their death. This selective targeting mechanism spares normal cells, reducing the risk of severe side effects associated with traditional chemotherapy.
Used in Cancer Research:
COH-29 is used as a research tool for studying the role of human ribonucleotide reductase (RRM2) in DNA replication and repair in cancer cells. Understanding the mechanism of action of COH-29 can provide valuable insights into the development of new cancer therapies and the identification of potential biomarkers for cancer diagnosis and prognosis.
Used in Drug Development:
COH-29 serves as a lead compound in the development of new cancer treatments. Its unique mechanism of action and potential for reduced side effects make it an attractive candidate for further research and optimization to improve its efficacy, bioavailability, and safety profile in clinical settings.