Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics
A five-step synthesis of an array of N-aryl-3-alkylidenepyrrolinones, which are potential Niemann-Pick type C (NPC) disease therapeutics, is described. The synthetic route allows for the production of analogues, including photoaffinity and biotinylated de
Cosner, Casey C.,Markiewicz, John T.,Bourbon, Pauline,Mariani, Christopher J.,Wiest, Olaf,Rujoi, Madalina,Rosenbaum, Anton I.,Huang, Amy Y.,Maxfield, Frederick R.,Helquist, Paul
supporting information; experimental part
p. 6494 - 6498
(2010/03/31)
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